Nimodipine, Bay-e-9736, Periplum, Admon, Nimotop
尼莫地平Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-isopropyl 5-(2-methoxyethyl) diester
CAS No. 66085-59-4
项目整合开发状态: Launched-1985
项目研究机构: Bayer (Originator), Esteve (Licensee), Italfarmaco (Licensee)
合成路线:By cyclocondensation of a mixture of isopropyl(m-nitrobenzylidene)acetylacetate (II),2-methoxyethyl acetylacetate (I) and NH3 in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:Nimodipine
文献作者:Castar,J.; Serradell,M.N.; Mealy,N.E.; Blancafort,P.; Leeson,P.A.
参考来源:Drugs Fut 1981,6(2),98
📄 详细内容
合成路线:By cyclocondensation of a mixture of isopropyl(m-nitrobenzylidene)acetylacetate (II),2-methoxyethyl acetylacetate (I) and NH3 in refluxing ethanol.
参考文献标题:Unsymmetrical esters of 1,4-dihydropyridine-3,5-dicarboxylic acid
文献作者:Meyer,H.; et al.
参考来源:BE 0781878; DE 2117571; FR 2132830; GB 1358951; US 3799934
产品链接: CAS No. 66085-59-4››