Amcinonide, CL-34699
安西奈德Chemical Name: 21-Acetoxy-9alpha-fluoro-11beta,16alpha,17-trihydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal whith cyclopentanone; 11beta,16alpha-Acetoxy-16,17[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxypregna-1,4-diene-3,20-dione; 16alpha,17alpha-Cyclopentylidenedioxy-9alpha-fluoro-11beta,21-dihydroxy-1,4-pregnadiene-3,20dione 21-acetate
CAS No. 51022-69-6
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:9alpha,fluoro-11beta16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione (I) is ketalized by reaction with cyclopentanone (II) by means of perchloric acid yielding the ketal (III),which is then acetylated by reaction with acetic anhydride in pyridine.
📌 参考资料/链接：
参考文献标题:Administration of 16alpha,17alpha-cyclopentylidenedioxy-9alpha-fluoro-11beta,21-dihydroxy-1,4-pregnadiene-3,20-dione-21-acetate
文献作者:Sieger,G.M.; Krieger,C.(American Cyanamid Co.)
参考来源:DE 2437847; FR 2240738; GB 1442925; US 4158055
📄 详细内容
合成路线:9alpha,fluoro-11beta16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione (I) is ketalized by reaction with cyclopentanone (II) by means of perchloric acid yielding the ketal (III),which is then acetylated by reaction with acetic anhydride in pyridine.
参考文献标题:Amcinodine
文献作者:Hillier,K.; Castar,J.
参考来源:Drugs Fut 1978,3(5),337
产品链接: CAS No. 51022-69-6››