SPD-420, BDP-12, CX-516, Ampalex

安帕来斯Chemical Name: 6-(Piperidin-1-ylcarbonyl)quinoxaline; 1-(Piperidin-1-yl)-1-(quinoxalin-6-yl)methanone
CAS No. 154235-83-3
项目整合开发状态: Phase II
项目研究机构: Cortex (Originator), University of California, Oakland (Originator), Cortex (Licensee), Organon (Licensee), Shire Pharmaceuticals (Licensee), Servier (Codevelopment)
合成路线:6-Quinoxalinecarboxylic acid (III) was prepared by condensation of 3,4-diaminobenzoic acid (I) with glyoxal (II).The title amide was then prepared by coupling of acid (III) with piperidine (VI) via formation of the mixed anhydride (IV) with pivaloyl chloride and Et3N or,alternatively,via activation of (III) as the imidazolide (V) by treatment with carbonyldiimidazole