Semapimod hydrochloride, AXD-455, CNI-1493

塞马莫德 Chemical Name: N,N'-Bis[3,5-bis[1-(2-amidinohydrazono)ethyl]phenyl]decanediamide tetrahydrochloride
CAS No. 164301-51-3, 352513-83-8 (free base)
项目整合开发状态: Phase II
项目研究机构: Picower Institute for Medical Research (Originator), Axxima (Licensee), Cytokine PharmaSciences (Licensee), Cytokine PharmaSciences (Codevelopment)
合成路线:The reaction of decanedioyl dichloride (I) with 3,5-diacetylaniline (II) by means of pyridine in dichloromethane gives the corresponding diamide (III),which is condensed with aminoguanidine (IV) in refluxing aqueous ethanol to afford the target tetrakis amidinohydrazone.