Ipexidine mesylate, CK-0569(free base)
伊培西定 Chemical Name: 1,1'-[Piperazin-1,4-diylbis(propane-3,1-diyliminocarbonimidoyl)]bis(3-hexylurea) bis(methanesulfonate)
CAS No. 69017-90-9, 69017-89-6 (free base)
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The reaction of S-methyl isothiouronium iodide (I) with n-hexyl isocyanate (II) by means of triethylamine in acetone gives N-(methylthioiminocarbonyl)-N?n-hexylurea (III),which is then condensed with 1,4-bis(3-aminopropyl)piperazine (IV) in refluxing isopropanol and methanesulfonic acid.
📌 参考资料/链接：
参考文献标题:
文献作者:Wohl,R.A.
参考来源:ZA 706373
📄 详细内容
合成路线:The reaction of S-methyl isothiouronium iodide (I) with n-hexyl isocyanate (II) by means of triethylamine in acetone gives N-(methylthioiminocarbonyl)-N?n-hexylurea (III),which is then condensed with 1,4-bis(3-aminopropyl)piperazine (IV) in refluxing isopropanol and methanesulfonic acid.
参考文献标题:Ipexidine Mesylate
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Leeson,P.A.; Mealy,N.E.
参考来源:Drugs Fut 1981,6(6),350
产品链接: CAS No. 69017-90-9›› 产品链接: CAS No.69017-89-6››