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项目整合精选>>>Amsacrine, CI-880, NSC-141549(HCl), SN-11841, NSC-249992, NSC-156303, m-AMSA, Amsidyl, Amecrin, Amsidine
Amsacrine, CI-880, NSC-141549(HCl), SN-11841, NSC-249992, NSC-156303, m-AMSA, Amsidyl, Amecrin, Amsidine
安吖啶 盐酸胺苯吖啶 Chemical Name: 4'-(9-Acridinylamino)methanesulfon-m-anisidine; N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamide
CAS No. 51264-14-3, 54301-15-4 (HCl), 54301-16-5 (monomethanesulfonate)
项目整合开发状态: Launched-1982
项目研究机构: Bristol-Myers Squibb (Originator), Pfizer (Originator)
合成路线:The reaction of 4-nitro-m-anisidine (I) with methanesulfonyl chloride in pyridine gives 4-nitromethanesulfony-m-anisidine (II),which is reduced with Fe and aqueous HCl yielding 4-aminomethanesulfony-m-anisidine (III) .Finally,this compound is condensed with 9-chloroacridine (IV).
📌 参考资料/链接：
参考文献标题:m-AMSA
文献作者:Paton,D.M.; Blancafort,P.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1980,5(6),277
📄 详细内容
合成路线:The reaction of 4-nitro-m-anisidine (I) with methanesulfonyl chloride in pyridine gives 4-nitromethanesulfony-m-anisidine (II),which is reduced with Fe and aqueous HCl yielding 4-aminomethanesulfony-m-anisidine (III) .Finally,this compound is condensed with 9-chloroacridine (IV).
参考文献标题:Potential antitumor agents.23.4'-(9-Acridinylamino)alkanesulfonanilide congeners bearing hydrophilic functionality
文献作者:Cain,B.F.; Atwell,G.J.; Denny,W.A.
参考来源:J Med Chem 1977,20(8),987-996
合成路线:The reaction of 4-nitro-m-anisidine (I) with methanesulfonyl chloride in pyridine gives 4-nitromethanesulfony-m-anisidine (II),which is reduced with Fe and aqueous HCl yielding 4-aminomethanesulfony-m-anisidine (III) .Finally,this compound is condensed with 9-chloroacridine (IV).
参考文献标题:Potential antitumor agents.16.4-(Acridin-9-ylamino)methanesulfonanilides
文献作者:Cain,B.F.; Atwell,G.J.; Denny,W.A.
参考来源:J Med Chem 1975,18(11),1110-17
合成路线:The reaction of 4-nitro-m-anisidine (I) with methanesulfonyl chloride in pyridine gives 4-nitromethanesulfony-m-anisidine (II),which is reduced with Fe and aqueous HCl yielding 4-aminomethanesulfony-m-anisidine (III) .Finally,this compound is condensed with 9-chloroacridine (IV).
参考文献标题:Potential antitumor agents.26.Anionic congeners of the 9-anilinoacridine
文献作者:Denny,W.A.; et al.
参考来源:J Med Chem 1977,21(1),5-10