Tulobuterol hydrochloride, HN-078(patch), C-78, Hokunalin, Berachin
妥布特罗Chemical Name: 1-(2-Chlorophenyl)-2-tert-butylaminoethanol hydrochloride
CAS No. 41570-61-0 (free base)
项目整合开发状态: Launched-1981
项目研究机构: Abbott (Originator), Mitsubishi Pharma (Originator)
合成路线:The oxidation of 2-chloroacetophenone (I) with SeO2 in dioxane-water gives 2-chlorophenylglyoxal (II),b.p.87-90 C/1 mm,which is then reductocondensed with tert-butylamine (III) and NaSH4 in ethanol.
📌 参考资料/链接：
参考文献标题:C 78
文献作者:Castar,J.; Thorpe,P.
参考来源:Drugs Fut 1976,1(5),217
📄 详细内容
合成路线:The oxidation of 2-chloroacetophenone (I) with SeO2 in dioxane-water gives 2-chlorophenylglyoxal (II),b.p.87-90 C/1 mm,which is then reductocondensed with tert-butylamine (III) and NaSH4 in ethanol.
参考文献标题:Verfahren zur Herstellung con Derivaten des Chlorbenzylalkohols
文献作者:Kato,H.; Kurata,S.
参考来源:BE 0788737; DE 2244737; ES 406646; FR 2154082; JP 48034848
产品链接: CAS No. 41570-61-0››