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项目整合精选>>>Ormaplatin, Tetraplatin, U-77233, NSC-276017(diastereomeric mixture), NSC-363812
Ormaplatin, Tetraplatin, U-77233, NSC-276017(diastereomeric mixture), NSC-363812
奥马铂Chemical Name: Tetrachloro(d,l-trans)-1,2-diaminocyclohexaneplatinum(IV); [OC-6-22-(trans)]-Tetrachloro(1,2-cyclohexanediamine-N,N')platinum
CAS No. 62816-98-2, 96392-97-1 (cis-isomer)
项目整合开发状态: Phase I
项目研究机构: National Cancer Institute (Originator), Pfizer (Originator)
合成路线:A new synthesis of [195mPt]-tetraplatin has been described: By reaction of potassium hexachloroplatinate (195Pt) with trans-1,2-cyclohexanediamine in water.
📌 参考资料/链接：
参考文献标题:Synthesis of [195mPt]-tetraplatin
文献作者:Wyrick,S.D.; Chaney,S.G.
参考来源:J Label Compd Radiopharm 1990,28(7),753
📄 详细内容
合成路线:Potassium tetrachloroplatinate (I) is treated with an equivalent amount of 1,2-diaminocyclohexane in degassed water under nitrogen.The precipitated complex (II) is filtered and washed with HCl,ethanol and diethyl ether.The precipitate is dissolved in N,N-dimethylformamide,filtered and reprecipitated by addition of methanol.The precipitate is collected and suspended in 0.5N HCl and treated with chlorine gas at 100 C to convert to the tetrachloroplatinum(IV) complex.Removal of excess chlorine and then solvent,dissolution in methanol,filtration and removal of the methanol by vacuum yields the yellow product (III) in about 83% yield.
参考文献标题:Synthesis,physical properties,and antitumor activity of tetraplatin and related tetrachloroplatinum(IV) stereoisomers of 1,2-diaminocyclohexane
文献作者:Anderson,W.K.; Quagliato,D.A.; Haugwitz,R.D.; Narayanan,V.L.; Wolpert-DeFilippes,M.K.
参考来源:Cancer Treat Rep 1986,70(8),997-1002
产品链接: CAS No. 62816-98-2››