Oxapadol, MD-720111
奥沙帕朵Chemical Name: 1-Phenyl-4,5-dihydro-1H,3H-1,4-epoxy[1,4]oxazepino[4,3-a]benzimidazole
CAS No. 56969-22-3
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The cyclization of o-phenylenediamine (I) with alpha-hydroxyphenylacetic acid (II) in refluxing aqueous HCl gives 2-(alpha-hydroxybenzyl)benzimidazol (III),which is oxidized with SeO2 in refluxing acetic acid yielding 2-benzoylbenzimidazol (lV).Finally this compound is cyclized with epichlorohydrin (V) by means of sodium ethoxide in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:
文献作者:Fauran,C.; et al.
参考来源:BE 820626; CA 1038380; CA 1047501; CH 591495; DE 2444194; FR 2257269; GB 1428597; JP 7559397; NL 7412989; US 3951968; ZA 7406096
📄 详细内容
合成路线:The cyclization of o-phenylenediamine (I) with alpha-hydroxyphenylacetic acid (II) in refluxing aqueous HCl gives 2-(alpha-hydroxybenzyl)benzimidazol (III),which is oxidized with SeO2 in refluxing acetic acid yielding 2-benzoylbenzimidazol (lV).Finally this compound is cyclized with epichlorohydrin (V) by means of sodium ethoxide in refluxing ethanol.
参考文献标题:Oxapadol
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Paton,D.M.
参考来源:Drugs Fut 1980,5(10),502
产品链接: CAS No. 56969-22-3››