Octenidine hydrochloride, Win-414642
奥替尼啶二盐酸盐 奥克太啶 Chemical Name: 1,1'-(Decane-1,10-diiyl)bis[4-(octylimino)-1,4-dihydropyridine] dihydrochloride
CAS No. 70775-75-6, 71251-02-0 (free base)
项目整合开发状态: Phase II
项目研究机构: Sanofi-Aventis (Originator)
合成路线:The condensation of octylamine (I) with 4-bromopyridine by heating at 180 C gives (4-octylamino)piridine (III),which is then allowed to react with 1,10-dichlorodecane by heating 120-80 C.
📌 参考资料/链接：
参考文献标题:Octenidine hydrochloride
文献作者:Castar,J.; Pento,J.T.
参考来源:Drugs Fut 1986,11(4),269
📄 详细内容
合成路线:The condensation of octylamine (I) with 4-bromopyridine by heating at 180 C gives (4-octylamino)piridine (III),which is then allowed to react with 1,10-dichlorodecane by heating 120-80 C.
参考文献标题:Bispyridinamines: A new class of topical antimicrobial agents as inhibitors of dental plaque
文献作者:Bailey,D.M.; DeGrazia,C.G.; Hoff,S.J.; Schulenberg,P.L.; O'Connor,J.R.; Paris,D.A.; Slee,A.M.
参考来源:J Med Chem 1984,27(11),1457
产品链接: CAS No. 70775-75-6›› 产品链接: CAS No.71251-02-0››