Orpanoxin, F-776
奥帕诺辛Chemical Name: 3-[5-(4-Chlorophenyl)-2-furyl]-3-hydroxypropionic acid
CAS No. 60653-25-0
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The condensation of 5-(4-chlorophenyl)-2-furaldehyde (I) with ethyl bromoacetate (A) by means of Zn in benzene gives ethyl 5-(4-chlorophenyl)-beta-hydroxy-2-furanpropanoate (II),which is then hydrolyzed with NaOH in refluxing aqueous ethanol.
📌 参考资料/链接：
参考文献标题:3-(5-aryl-2-furyl)-3-hydroxypropionic acids and ethyl esters
文献作者:Pelosi,S.S.Jr.(Norwich Eaton)
参考来源:DE 2637596; ES 448530; FR 2321286; GB 1479264; US 3962284
📄 详细内容
合成路线:The condensation of 5-(4-chlorophenyl)-2-furaldehyde (I) with ethyl bromoacetate (A) by means of Zn in benzene gives ethyl 5-(4-chlorophenyl)-beta-hydroxy-2-furanpropanoate (II),which is then hydrolyzed with NaOH in refluxing aqueous ethanol.
参考文献标题:Orpanoxin
文献作者:Castar,J.; Blancafort,P.
参考来源:Drugs Fut 1978,3(12),888
产品链接: CAS No. 60653-25-0››