Olpadronic acid sodium salt, Dimethyl-APD, IG-8801

奥帕膦酸钠Chemical Name: 3-(Dimethylamino)-1-hydroxypropylidene-1,1-diphosphonic acid monosodium salt
CAS No. 63132-39-8 (free acid)
项目整合开发状态: Phase III
项目研究机构: Gador (Originator), Henkel (Not Determined)
合成路线:In order to obtain 3-(dimethylamino)-1-hydroxypropylidene-1,1-bisphosphonic acid (II),transfer 3-(dimethylamino)propionitrile (I) to a reactor,add water and PCl3; then slowly add POCl3 and finally water.Filter with reduced pressure and wash the solid with methanol.Place in an oven with forced air circulation until the solid is dry.To obtain the sodium salt (III) add NaOH to acid (II),filter,add methanol and dry in an oven with forced air circulation until constant weight.The 3-(dimethylamino)-1-hydroxypropylidene-1,1-bisphosphonic acid monosodium salt (III) is then obtained.