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Oxcarbazepine, KIN-493, GP-47680, Trileptal

奥卡西平Chemical Name: 10-Oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
CAS No. 28721-07-5
项目整合开发状态: Launched-1990
项目研究机构: Novartis (Originator), Kissei (Licensee)
合成路线:2) The nitration of 5-cyano 5H-dibenz[f,b]azepine (IV) with NaNO2 in acetic anhydride - acetic acid gives 5-cyano 10-nitro-5H-dibenz[b,f]azepine (V),which is then treated with BrF3 and powdered Fe in hot acetic acid.
📌 参考资料/链接:
参考文献标题:Process for the manufacture of 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine
文献作者:Aufderhaar,E.(Novartis AG)
参考来源:DD 153835; EP 0028028; JP 1045366; JP 1045367; JP 1045368; US 4452738; US 4540514; US 4559174; US 4579683

📄 详细内容


合成路线:1) The reaction of 10-methoxy-5H-dibenz[b,f]azepine (I) with phosgene in hot toluene gives 10-methoxy-5H-dibenz[b,f]azepine-5-carbonyl chloride (II),which is treated with NH3 in refluxing ethanol to afford 10-methoxy-5H-dibenz[b,f]azepine-5-carboxamide (III).Finally,this compound is hydrolyzed with refluxing 2N HCl.

参考文献标题:Process for the preparation of new azepine deriv.
文献作者:Schindler,W.(Novartis AG)
参考来源:DE 2011087


合成路线:This compound has been obtained by two related ways:1.The hydrolysis of 10-methoxy-5H-dibenzo[b,f]azepine (I) with refluxing 2N HCl gives 10,11-dihydro-5H-dibenzo[b,f]azepin-5-one (II),which is then treated with chlorosulfonyl isocyanate in chloroform to yield the target carboxamide.2.The reaction of 10-methoxy-5H-dibenzo[b,f]azepine (I) with potassium cyanate in hot sulfuric acid also gives the target carboxamide.In this reaction sodium cyanate can also be used instead of the potassium salt.Other strong acids such as trichloroacetic acid or anhydrous HCl in acetic acid can be used instead of sulfuric acid.

参考文献标题:A process for the preparation of 10-oxo-10,11-dihydro-5H-dibenzo(b,f)azepin-5-carboxamide
文献作者:Milanese,A.
参考来源:WO 9621649


合成路线:1) The reaction of 10-methoxy-5H-dibenz[b,f]azepine (I) with phosgene in hot toluene gives 10-methoxy-5H-dibenz[b,f]azepine-5-carbonyl chloride (II),which is treated with NH3 in refluxing ethanol to afford 10-methoxy-5H-dibenz[b,f]azepine-5-carboxamide (III).Finally,this compound is hydrolyzed with refluxing 2N HCl.

合成路线:2) The nitration of 5-cyano 5H-dibenz[f,b]azepine (IV) with NaNO2 in acetic anhydride - acetic acid gives 5-cyano 10-nitro-5H-dibenz[b,f]azepine (V),which is then treated with BrF3 and powdered Fe in hot acetic acid.

参考文献标题:Oxcarbazepine
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1986,11(10),844


合成路线:A new process for the preparation of oxcarbamazepine has been reported: Reaction of 1-phenyl-2,3-dihydro-1H-indol-2-one (I) with NaOH in refluxing THF gives 2-[2-(phenylamino)phenyl]acetic acid (II),which is condensed with dimethyl carbonate (III) by means of butyl lithium in the same solvent to yield 2-[2-[N-(methoxycarbonyl)-N-phenylamino]phenyl]acetic acid (IV).Cyclization of compound (IV) by means of polyphosphoric acid (PPA) at 100 C,followed by treatment of the reaction mixture with hot methanol (65 C) affords 10-methoxy-5H-dibenzo[b,f]azepine-5-carboxylic acid methyl ester (V),which is treated with NaOH in polyethyleneglycol at 100 C to provide 10-methoxy-5H-dibenzo[b,f]azepine (VI).Reaction of (VI) with sodium cyanate in acetic acid gives 10-methoxy-5H-dibenzo[b,f]azepine-5-carboxamide (VII),which is finally treated with H2SO4.

参考文献标题:Dibenzo [b,f]azepine derivs.and their preparation
文献作者:Kaufmann,D.; Lohse,O.; Zaugg,W.; F黱fschilling,P.; Beutler,U.(Novartis AG; Novartis-Erfindungen VmbH)
参考来源:WO 0156992


合成路线:Syntheses of intermediate (V),5-benzyl-10,11-dihydro-5H-dibenz[b,f]azepin-10-one: Cyclization of either 2-[N-benzyl-N-(2-methylphenyl)amino]-N,N-dimethylbenzamide (I),2-[N-benzyl-N-(2-methylphenyl)amino]-N,N-diethylbenzamide (II),2-[N-benzyl-N-(2-methylphenyl)amino]-N,N-diisopropylbenzamide (III) or the morpholine derivative (IV) by means of LDA and TMEDA in THF.

合成路线:Syntheses of intermediate (VIII),5-(4-methoxybenzyl)-10,11-dihydro-5H-dibenz[b,f]azepin-10-one: Cyclization of 2-[N-(4-methoxybenzyl)-N-(2-methylphenyl)amino]-N,N-dimethylbenzamide (VI) or 2-[N-(4-methoxybenzyl)-N-(2-methylphenyl)amino]-N,N-diethylbenzamide (VII)) by means of LDA and TMEDA in THF.

合成路线:Syntheses of intermediate (XI),5-allyl-10,11-dihydro-5H-dibenz[b,f]azepin-10-one: Cyclization of 2-[N-allyl-N-(2-methylphenyl)amino]-N,N-dimethylbenzamide (IX) or 2-[N-allyl-N-(2-methylphenyl)amino]-N,N-diethylbenzamide (X) by means of LDA and TMEDA in THF.

合成路线:Finally,deprotection of either intermediate (V) with TMS-Cl and NaI,intermediate (VIII) with TiCl4 or intermediate (XI) with Rh(PPh3)3Cl give,in all cases,10,11-dihydro-5H-dibenz[b,f]azepin-10-one (XII),which is finally treated with chlorosulfonyl isocyanate to afford oxcarbazepine.
参考文献标题:New synthesis of oxcarbazepine via remote metalation of protected N-o-tolyl-anthranilamide derivatives
文献作者:Lohse,O.; Kaufmann,D.; France,J.; Beutler,U.; Funfschilling,P.; Zaugg,W.; Furet,P.
参考来源:Tetrahedron Lett 2001,42(3),385


产品链接: CAS No. 28721-07-5››