Oritavancin, LY-333328
奥利万星 奥利万星二磷酸盐 Chemical Name: (3S,6R,7R,22R,23S,26S,36R,38aR)-22-(3-Amino-2,3,6-trideoxy-3-C-methyl-alpha-L-mannopyranosyloxy)-3-(carbamoylmethyl)-10,19-dichloro-44-[2-O-[3-(4'-chlorobiphenyl-4-ylmethylamino)-2,3,6-trideoxy-3-C-methyl-alpha-L-mannopyranosyl]-beta-D-glucopyranosyloxy]-7,28,30,32-tetrahydroxy-6-(N2-methyl-D-leucylamido)-2,5,24,38,39-pentaoxo-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-1H,22H-8,11:18,21-dietheno-23,26-(iminomethano)-13,16:31,35-dimetheno[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid; (4''R)-22-O-(3-Amino-2,3,6-trideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-N3''-(4'-chloro[1,1'-biphenyl]-4-ylmethyl)vancomycin
CAS No. 171099-57-3, 192564-14-0 (phosphate salt)
项目整合开发状态: Phase III
项目研究机构: Abbott (Supplier), Lilly (Originator), InterMune (Licensee)
合成路线:LY-333328 was synthesized by reductocondensation of the glycopeptide antibiotic A82846B (I) with 4'-chlorobiphenyl-4-carboxaldehyde (II) by means of sodium cyanoborohydride in refluxing methanol.
📌 参考资料/链接：
参考文献标题:Glycopeptide antibiotic derivs
文献作者:Cooper,R.D.G.; Huff,B.E.; Nicas,T.I.; Quatroche,J.T.; Rodriguez,M.J.; Snyder,N.J.; Staszak,M.A.; Thompson,R.C.; Wilkie,S.C.; Zweifel,M.J.(Eli Lilly and Company)
参考来源:EP 0817797; JP 1999502534; WO 9630401
📄 详细内容
合成路线:LY-333328 was synthesized by reductocondensation of the glycopeptide antibiotic A82846B (I) with 4'-chlorobiphenyl-4-carboxaldehyde (II) by means of sodium cyanoborohydride in refluxing methanol.
参考文献标题:Glycopeptide antibiotic derivs
文献作者:Cooper,R.D.G.; Huff,B.E.; Nicas,T.I.; Quatroche,J.T.; Rodriguez,M.J.; Snyder,N.J.; Staszak,M.A.; Thompson,R.C.; Wilkie,S.C.; Zweifel,M.J.(Eli Lilly and Company)
参考来源:EP 0667353; EP 1016670; EP 1031576
合成路线:LY-333328 was synthesized by reductocondensation of the glycopeptide antibiotic A82846B (I) with 4'-chlorobiphenyl-4-carboxaldehyde (II) by means of sodium cyanoborohydride in refluxing methanol.
参考文献标题:Reductive alkylation of glycopeptide antibiotics: Synthesis and antibacterial activity
文献作者:Cooper,R.D.G.; Snyder,N.J.; Zweifel,M.J.; Staszak,M.A.; Wilkie,S.C.; Nicas,T.I.; Mullen,D.L.; Butler,T.F.; Rodriguez,M.J.; Huff,B.E.; Thompson,R.C.
参考来源:J Antibiot 1996,49(6),575-81
合成路线:LY-333328 was synthesized by reductocondensation of the glycopeptide antibiotic A82846B (I) with 4'-chlorobiphenyl-4-carboxaldehyde (II) by means of sodium cyanoborohydride in refluxing methanol.
参考文献标题:LY-333328
文献作者:Fromtling,R.A.; Castar,J.
参考来源:Drugs Fut 1998,23(1),17
产品链接: CAS No. 171099-57-3›› 产品链接: CAS No.192564-14-0››