Dinazafone, F-1797
地那扎封Chemical Name: N1-(2-Benzoyl-4-chlorophenyl)-N1-methyl-N2-(2-methyl-2-propenyl)glycinamide
CAS No. 71119-12-5
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The tosylation of 2-amino-5-chlorobenzophenone (I) with tosyl chloride (II) in pyridine gives 2-tosylamido-5-chlorobenzophenone (III),which is methylated with dimethyl sulfate and sodium methoxide in toluene yielding N-methyl-2-tosylamido-5-chlorobenzophenone (IV).Hydrolysis of (IV) with aqueous sulfuric acid affords 2-methylamino-5-chlorobenzophenone (V),which is acylated with bromoacetyl chloride (VI) in benzene to give N-methyl-2-(bromoacetylamido)-5-chlorobenzophenone (VII).Finally this compound is condensed with 2-methylallylamine (VIII) in acetone
📌 参考资料/链接：
参考文献标题:Dinazafone
文献作者:Serradell,M.N.; Castar,J.; Souto,M.
参考来源:Drugs Fut 1984,9(7),501
📄 详细内容
合成路线:The tosylation of 2-amino-5-chlorobenzophenone (I) with tosyl chloride (II) in pyridine gives 2-tosylamido-5-chlorobenzophenone (III),which is methylated with dimethyl sulfate and sodium methoxide in toluene yielding N-methyl-2-tosylamido-5-chlorobenzophenone (IV).Hydrolysis of (IV) with aqueous sulfuric acid affords 2-methylamino-5-chlorobenzophenone (V),which is acylated with bromoacetyl chloride (VI) in benzene to give N-methyl-2-(bromoacetylamido)-5-chlorobenzophenone (VII).Finally this compound is condensed with 2-methylallylamine (VIII) in acetone
参考文献标题:
文献作者:Mouzin,G.; Cousse,H.; Stenger,A.; Casadio,S.(Pierre Fabre S.A.)
参考来源:US 4372975
产品链接: CAS No. 71119-12-5››