Detorubicin, RP-33921, DEA-14-DNR
地托比星Chemical Name: 14-Diethoxyacetoxydaunorubicin; Glycoxylic acid 3(2)-ester with doxorubicin,2-(diethyl acetal); [(2S,4S)-4-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]carbonyl]methyl glyoxylate 2-(diethyl acetal); Diethoxyacetic acid (2S-cis)-2-[4-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-oxoethyl ester
CAS No. 66211-92-5
项目整合开发状态: Biological Testing
项目研究机构: Aventis Pharma (Originator), Wyeth Pharmaceuticals (Licensee)
合成路线:The ketalization of daunorubicin (I) in the usual way gives daunorubicin-13-dimethylketal (II),which is brominated to 14-bromodaunorubicin-13-dimethylketal (III).The hydrolysis of (III) yields 14-bromodaunorubicin (IV),which is finally treated with sodium diethoxyacetate in refluxing acetone.The title product can also be obtained by reaction of (III) with sodium diethoxyacetate (A) in the same way.
📌 参考资料/链接：
参考文献标题:Detorubicin
文献作者:Blancafort,P.; Bernard,J.; Castar,J.; Serradell,M.N.; Jacquillat,C.
参考来源:Drugs Fut 1981,6(3),139
📄 详细内容
合成路线:The ketalization of daunorubicin (I) in the usual way gives daunorubicin-13-dimethylketal (II),which is brominated to 14-bromodaunorubicin-13-dimethylketal (III).The hydrolysis of (III) yields 14-bromodaunorubicin (IV),which is finally treated with sodium diethoxyacetate in refluxing acetone.The title product can also be obtained by reaction of (III) with sodium diethoxyacetate (A) in the same way.
参考文献标题:Preparation and experimental antitumor activity of a new semi-synthetic compound: 14-Diethoxy daunorubicin (RP 33921)
文献作者:Maral,R.; et al.
参考来源:Compt Rend Acad Sci 1978,443-446
产品链接: CAS No. 66211-92-5››