合成路线:Imitrodast can be obtained by two related ways:1) The carboxylation of 4,5,6,7-tetrahydrobenzo[b]thiophen-7-one (I) with dimethyl carbonate by means of NaH in DMF gives 7-oxo-4,5,6,7-tetrahydro[b]thiophene-6-carboxylic acid methyl ester (II) (1,2),which is reduced with NaBH4 and dehydrated with p-toluenesulfonic acid yielding 4,5-dihydrobenzo[b]thiophene-6-carboxylic acid methyl ester (III).The formylation of (III) with dichloromethyl methyl ether and AlCl3 in methylene chloride affords the corresponding 2-formyl derivative (IV),which is reduced with NaBH4 in methanol/THF to the hydroxymethyl derivative (V).The reaction of (V) with SOCl2 in dichloromethane gives the chloromethyl derivative (VI),which is condensed with the sodium derivative of imidazole (VII) by means of 4-(dimethylamino)pyridine in dichloromethane yielding 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylic acid methyl ester (VIII).Finally,this compound is hydrolyzed with NaOH in aqueous ethanol.
合成路线:2) The formylation of 4-(3-thienyl)butyric acid ethyl ester (IX) with dichloromethyl methyl ether and SnCl4 in dichloromethane gives 4-(2-formylthien-3-yl)butyric acid ethyl ester (X),which is cyclized with sodium ethoxide (NaH/ethanol) in hot toluene yielding 4,5-dihydrobenzo[b]thiophene-6-carboxylic acid ethyl ester ester (XI).
参考文献标题:Production method of thianaphthene derivs
文献作者:Terada,A.; Amemiya,Y.; Wachi,K.(Sankyo Co.,Ltd.)
参考来源:JP 1989050879
合成路线:Imitrodast can be obtained by two related ways:1) The carboxylation of 4,5,6,7-tetrahydrobenzo[b]thiophen-7-one (I) with dimethyl carbonate by means of NaH in DMF gives 7-oxo-4,5,6,7-tetrahydro[b]thiophene-6-carboxylic acid methyl ester (II) (1,2),which is reduced with NaBH4 and dehydrated with p-toluenesulfonic acid yielding 4,5-dihydrobenzo[b]thiophene-6-carboxylic acid methyl ester (III).The formylation of (III) with dichloromethyl methyl ether and AlCl3 in methylene chloride affords the corresponding 2-formyl derivative (IV),which is reduced with NaBH4 in methanol/THF to the hydroxymethyl derivative (V).The reaction of (V) with SOCl2 in dichloromethane gives the chloromethyl derivative (VI),which is condensed with the sodium derivative of imidazole (VII) by means of 4-(dimethylamino)pyridine in dichloromethane yielding 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylic acid methyl ester (VIII).Finally,this compound is hydrolyzed with NaOH in aqueous ethanol.
参考文献标题:Synthesis and thromboxane synthetase inhibitory activity of di- or tetrahydrobenzo[b]thiophenecarboxylic acid derivatives
文献作者:Amemiya,Y.; et al.
参考来源:J Med Chem 1989,32(6),1265-72
合成路线:Imitrodast can be obtained by two related ways:1) The carboxylation of 4,5,6,7-tetrahydrobenzo[b]thiophen-7-one (I) with dimethyl carbonate by means of NaH in DMF gives 7-oxo-4,5,6,7-tetrahydro[b]thiophene-6-carboxylic acid methyl ester (II) (1,2),which is reduced with NaBH4 and dehydrated with p-toluenesulfonic acid yielding 4,5-dihydrobenzo[b]thiophene-6-carboxylic acid methyl ester (III).The formylation of (III) with dichloromethyl methyl ether and AlCl3 in methylene chloride affords the corresponding 2-formyl derivative (IV),which is reduced with NaBH4 in methanol/THF to the hydroxymethyl derivative (V).The reaction of (V) with SOCl2 in dichloromethane gives the chloromethyl derivative (VI),which is condensed with the sodium derivative of imidazole (VII) by means of 4-(dimethylamino)pyridine in dichloromethane yielding 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylic acid methyl ester (VIII).Finally,this compound is hydrolyzed with NaOH in aqueous ethanol.
合成路线:2) The formylation of 4-(3-thienyl)butyric acid ethyl ester (IX) with dichloromethyl methyl ether and SnCl4 in dichloromethane gives 4-(2-formylthien-3-yl)butyric acid ethyl ester (X),which is cyclized with sodium ethoxide (NaH/ethanol) in hot toluene yielding 4,5-dihydrobenzo[b]thiophene-6-carboxylic acid ethyl ester ester (XI).
参考文献标题:Imitrodast Sodium
文献作者:Nerlos,M.; Leeson,P.; Castar,J.
参考来源:Drugs Fut 1997,22(7),715
产品链接: CAS No. 113817-57-5›› 产品链接: CAS No.114686-12-3››