Dotarizine, FI-6026
多他利嗪Chemical Name: 1-(Diphenylmethyl)-4-[3-(2-phenyl-1,3-dioxolan-2- yl)propyl]piperazine
CAS No. 84625-59-2
项目整合开发状态: Phase III
项目研究机构: Ferrer (Originator), Bertek (Licensee), Galephar PR (Licensee)
合成路线:The title compound was synthesized by alkylation of 1-benzhydrylpiperazine (I) with 2-(3-chloropropyl)-2-phenyl-1,3-dioxolan (II) in the presence of NaHCO3 in refluxing EtOH.
📌 参考资料/链接：
参考文献标题:Piperazine derivs.,a process for preparing them and pharmaceutical compsns.
文献作者:Foguet,R.; Gubert,S.; Raga,M.M.; Ortiz,J.A.; Sacrist醤,A.(Ferrer Internacional SA)
参考来源:EP 0097340