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项目整合精选>>>Azelaic acid, ZK-62498, AGN-191861, SH-441, Finacea, Finevin, Azelex, Skinoren, Skinorem
Azelaic acid, ZK-62498, AGN-191861, SH-441, Finacea, Finevin, Azelex, Skinoren, Skinorem
壬二酸壬二酸钠盐(1:2)Chemical Name: 1,7-Heptanedicarboxylic acid; Nonanedioic acid
CAS No. 123-99-9, 14488-58-5 (Ca salt (1:1)), 17265-13-3 (diNa salt)
项目整合开发状态: Launched-1989
项目研究机构: Berlex (Originator), Schering AG (Originator), Allergan (Licensee)
合成路线:The hydrolysis of glycerol ricinoleate (castor oil) (I) with KOH in refluxing 95% ethanol gives ricinoleic acid (II),which is oxidized with KMnO4 in water with KOH.
📌 参考资料/链接：
参考文献标题:Azelaic Acid
文献作者:Castar,J.; Passi,S.; Serradell,M.N.; Picardo,M.; Porro,M.N.; Blancafort,P.
参考来源:Drugs Fut 1983,8(1),9
📄 详细内容
合成路线:The hydrolysis of glycerol ricinoleate (castor oil) (I) with KOH in refluxing 95% ethanol gives ricinoleic acid (II),which is oxidized with KMnO4 in water with KOH.
参考文献标题:Azelaic acid
文献作者:Hill,J.W.; McEwen,W.L.
参考来源:Org Synth Coll 1943,II53-55