Pelubiprofen, CS-670, RS-2131
培鲁比洛芬Chemical Name: (?-(E)-alpha-Methyl-4-[(2-oxocyclohexylidene)methyl]benzeneacetic acid; (?-(E)-2-[4-(2-Oxocyclohexylidenemethyl)phenyl]propionic acid
CAS No. 69956-77-0
项目整合开发状态: Phase III
项目研究机构: Sankyo (Originator)
合成路线:The condensation of pyrrolidinocyclohexene (I) with ethyl 2-(4-formylphenyl)propionate (II) in refluxing benzene gives ethyl 2-[4-(2-oxocyclohexylidenemethyl)phenyl)propionate (III),which is hydrolyzed with HBr in refluxing dioxane water.
📌 参考资料/链接：
参考文献标题:Cycloalkylidenemethylphenylacetic acid derivatives and process for the preparation thereof
文献作者:Terada,A.; Tanaka,S.; Misaka,E.(Sankyo Co.,Ltd.)
参考来源:BE 0869721; DE 2835701; FR 2400500; GB 2002762; JP 7932460; JP 8257019; US 4254274; US 4365076
📄 详细内容
合成路线:The condensation of pyrrolidinocyclohexene (I) with ethyl 2-(4-formylphenyl)propionate (II) in refluxing benzene gives ethyl 2-[4-(2-oxocyclohexylidenemethyl)phenyl)propionate (III),which is hydrolyzed with HBr in refluxing dioxane water.
参考文献标题:RS-2131
文献作者:Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1984,9(4),275
产品链接: CAS No. 69956-77-0››