合成路线:The cyclization of acetamidine (I) with 2-cyano-3,3-bis(methylthio)-2-propenoic acid methyl ester (II) by means ot NaH in DMF gives 2-methyl-6-(methylthio)-4 oxo-1,4-dihydropyrimidine-5-carbonitrile (III),which is then condensed with 3-pyridylmethyl amine (IV) by refluxing in dimethoxyethane solution.
参考文献标题:Pelrinone hydrochloride
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1988,13(8),728
合成路线:The cyclization of acetamidine (I) with 2-cyano-3,3-bis(methylthio)-2-propenoic acid methyl ester (II) by means ot NaH in DMF gives 2-methyl-6-(methylthio)-4 oxo-1,4-dihydropyrimidine-5-carbonitrile (III),which is then condensed with 3-pyridylmethyl amine (IV) by refluxing in dimethoxyethane solution.
参考文献标题:Chemistry and positive inotropic effect of pelrino
文献作者:Bagli,J.; Bogri,T.; Palameta,B.; Rakhit,S.; Peseckis,S.; McQuillan,J.; Lee,D.K.
参考来源:J Med Chem 1988,31(4),814-23
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