网站主页>>>
项目整合精选>>>
项目整合精选>>>NSC-704057, KOS-953, 17-AAG, CP-127374, NSC-330507D, NSC-330507
NSC-704057, KOS-953, 17-AAG, CP-127374, NSC-330507D, NSC-330507
坦螺旋霉素Chemical Name: (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-9-(carbamoyloxy)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaene-3,20,22-trione; 17-(Allylamino)-17-demethoxygeldanamycin
CAS No. 75747-14-7
项目整合开发状态: Phase II
项目研究机构: Kosan (Orphan Drug), Kosan (Originator), Pfizer (Originator), Kosan (Codevelopment), National Cancer Institute (Codevelopment)
合成路线:The title compound was prepared by displacement of the 17-methoxy group of geldanamycin (I) with allylamine (II) in chloroform at room temperature.
📌 参考资料/链接：
参考文献标题:Geldanamycin derivs.and antitumor drug
文献作者:Inoue,Y.; Sasaki,K.(Kaken Pharmaceutical Co.,Ltd.)
参考来源:US 4261989
📄 详细内容
合成路线:The title compound was prepared by displacement of the 17-methoxy group of geldanamycin (I) with allylamine (II) in chloroform at room temperature.
参考文献标题:erbB-2 oncogene inhibition by geldanamycin derivatives: Synthesis,mechanism of action,and structure-activity relationships
文献作者:Schnur,R.C.; Corman,M.L.; Gallaschun,R.J.; Cooper,B.A.; Dee,M.F.; Doty,J.L.; Muzzi,M.L.; DiOrio,C.I.; Barbacci,E.G.; Miller,P.E.; et al.
参考来源:J Med Chem 1995,38(19),3813
产品链接: CAS No. 75747-14-7››