Demetacin, Delmetacin, UR-2310
地美辛Chemical Name: 1-Benzoyl-2-methylindole-3-acetic acid; 2-(1-Benzoyl-2-methylindol-3-yl)acetic acid
CAS No. 16401-80-2
项目整合开发状态: Clinical
项目研究机构: Uriach (Originator)
合成路线:The phenylhydrazone of benzaldehyde (I) is obtained in the usual way,phenylhydrazine (A) with benzaldehyde (B),which by reaction with benzoyl chloride (II) gives (C) and further treatment with HCl in an organic solvent results in the substituted hydrazine hydrochloride (III).Finally,this compound is condensed with levulinic acid (IV) at high temperature.
📌 参考资料/链接：
参考文献标题:Delmetacin
文献作者:Francia,E.; Garc韆 Rafanell,J.
参考来源:Drugs Fut 1983,8(9),764
📄 详细内容
合成路线:The phenylhydrazone of benzaldehyde (I) is obtained in the usual way,phenylhydrazine (A) with benzaldehyde (B),which by reaction with benzoyl chloride (II) gives (C) and further treatment with HCl in an organic solvent results in the substituted hydrazine hydrochloride (III).Finally,this compound is condensed with levulinic acid (IV) at high temperature.
参考文献标题:Procedimiento de obtenci髇 del 醕ido 1-benzoil-2-metilindol-3-ac閠ico
文献作者:Franc韆,E.; Mar韓,A.(Uriach & Cia S.A.)
参考来源:ES 471436
产品链接: CAS No. 16401-80-2››