Diprafenone
地丙苯酮Chemical Name: (?-2'-[2-Hydroxy-3-(tert-pentylamino)propoxy]-3- phenylpropiophenone
CAS No. 81447-80-5, 86342-43-0 (HCl)
项目整合开发状态: Phase III
项目研究机构: Helopharm (Originator)
合成路线:The condensation of 2'-hydroxy-3-phenylpropiophenone (I) with 1 chloro-2,3-epoxypropane (II) by means of K2CO3 gives 2'-(2,3-epoxypropoxy)-3-phenylpropiophenone (III),which is then treated with 2-methyl-2-aminobutane (IV) in refluxing methanol.
合成路线:The reaction of ethyl 3-(2-benzylphenyl)-1-methyl-4-oxopiperidine-5-carboxylate (I) with refluxing 5N HCl gives a mixture of 3-(2-benzylphenyl)-1-methyl-4 piperidone (II) and MO-8282.The inter mediate product (II) is cyclized by heating at 100 C with polyphosphoric acid (PPA).
📌 参考资料/链接：
参考文献标题:2-[2'-Hydroxy-3'-(1,1-dimethylpropylamino)-propoxy]-beta-phenylpropiophenone,its physiologically acceptable acid addition salts,and pharmaceutical compsns.
文献作者:Petrik,G.; Sachse,R.(Helopharm KG)
参考来源:DE 3133814; US 4460605
📄 详细内容
合成路线:The condensation of 2'-hydroxy-3-phenylpropiophenone (I) with 1 chloro-2,3-epoxypropane (II) by means of K2CO3 gives 2'-(2,3-epoxypropoxy)-3-phenylpropiophenone (III),which is then treated with 2-methyl-2-aminobutane (IV) in refluxing methanol.
参考文献标题:Difrafenone
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1986,11(8),645
产品链接: CAS No. 81447-80-5›› 产品链接: CAS No.86342-43-0››