Cimadronate sodium, Incadronic acid sodium salt, YM-175, YM-21175-1, Bisphonal
因卡磷酸二钠 英卡膦酸 Chemical Name: Cycloheptylaminomethylenedi(phosphonic acid) disodium salt; [(Cycloheptylamino)methylene]bisphosphonic acid disodium salt
CAS No. 138330-18-4, 124351-85-5 (free acid), 157432-63-8 (Mg salt), 183808-97-1 (monohydrate), 157432-62-7 (Zn salt)
项目整合开发状态: Launched-1997
项目研究机构: Yamanouchi (Originator)
合成路线:The reaction of cycloheptylamine (I) with triethyl orthoformate (II) and diethyl phosphite (III) at 150 gives cycloheptylaminomethylenediphosphonic acid tetraethyl ester (IV),which is then hydrolyzed with refluxing concentrated hydrochloric acid.
📌 参考资料/链接：
参考文献标题:(Cycloalkylamino)methylenebisphosphonic acids and medicines containing them
文献作者:Isomura,Y.; Takeuchi,M.; Sakamoto,S.; Abe,T.(Yamanouchi Pharmaceutical Co.,Ltd.)
参考来源:AU 8928670; EP 0325482; JP 1989308290; US 5041428
📄 详细内容
合成路线:The reaction of cycloheptylamine (I) with triethyl orthoformate (II) and diethyl phosphite (III) at 150 gives cycloheptylaminomethylenediphosphonic acid tetraethyl ester (IV),which is then hydrolyzed with refluxing concentrated hydrochloric acid.
参考文献标题:Synthesis and structure-activity relationships of a novel anti-resorptive agent YM175,and the related derivatives
文献作者:Takeuchi,M.; Sakamoto,S.; Kawamuki,K.; Kudo,M.; Murase,K.; Kawashima,H.; Isomura,Y.
参考来源:Symp Med Chem 1990,P-12
合成路线:The reaction of cycloheptylamine (I) with triethyl orthoformate (II) and diethyl phosphite (III) at 150 gives cycloheptylaminomethylenediphosphonic acid tetraethyl ester (IV),which is then hydrolyzed with refluxing concentrated hydrochloric acid.
参考文献标题:YM-175
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1992,17(4),293
产品链接: CAS No. 138330-18-4›› 产品链接: CAS No.124351-85-5››