合成路线:Compound can be prepared in three different ways:1) The reduction of cytidine (I) with H2 over Rh/Al2O3 in water in a Parr apparatus at 2.8 bar gives 3,4,5,6-tetrahydrocytidine (II),which is then hydrolyzed with water at pH 5.5.2) The reduction of uridine (III) with H2 over Rh/Al2O3 as before gives 5,6-dihydrouridine (IV),which is then reduced again with NaBH4 in water or with H2 over Rh/Al2O3 in water containing ammonia.3) The reduction of (III) can also be performed in a single step with H2 over Rh/Al2O3 in water containing NH3,in a Parr apparatus at 2.94 bar.
参考文献标题:Nucleic acids.IV.The catalytic reduction of pyrimidine nucleosides (human liver deaminase inhibitors)
文献作者:Hanze,A.R.
参考来源:J Am Chem Soc 1967,89(25),6720-25
合成路线:Compound can be prepared in three different ways:1) The reduction of cytidine (I) with H2 over Rh/Al2O3 in water in a Parr apparatus at 2.8 bar gives 3,4,5,6-tetrahydrocytidine (II),which is then hydrolyzed with water at pH 5.5.2) The reduction of uridine (III) with H2 over Rh/Al2O3 as before gives 5,6-dihydrouridine (IV),which is then reduced again with NaBH4 in water or with H2 over Rh/Al2O3 in water containing ammonia.3) The reduction of (III) can also be performed in a single step with H2 over Rh/Al2O3 in water containing NH3,in a Parr apparatus at 2.94 bar.
参考文献标题:Tetrahydrouridine
文献作者:Woodman,R.J.
参考来源:Drugs Fut 1979,4(4),283
产品链接: CAS No. 18771-50-1››