Tianeptine sodium, S-1574, Stablon
噻奈普汀钠盐 噻奈普汀 (+)-噻奈普汀单钠盐Chemical Name: 7-(3-Chloro-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide sodium salt
CAS No. 30123-17-2, 66981-73-5 (free acid), 54317-11-2 (racemate)
项目整合开发状态: Launched-1988
项目研究机构: Servier (Originator), Vela Pharmaceuticals (Not Determined)
合成路线:The condensation of 3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine S,S-dioxide (I) with ethyl 7-aminoheptanoate (II) in nitromethane gives ethyl 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoate S,S-dioxide (III),which is then hydrolyzed with NaOH in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:S-1574
文献作者:Castar,J.; Neuman,M.; Blancafort,P.; Serradell,M.N.
参考来源:Drugs Fut 1979,4(7),522
📄 详细内容
合成路线:The condensation of 3,11-dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine S,S-dioxide (I) with ethyl 7-aminoheptanoate (II) in nitromethane gives ethyl 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoate S,S-dioxide (III),which is then hydrolyzed with NaOH in refluxing ethanol.
参考文献标题:Tricyclic compounds
文献作者:Malen,C.; et al.
参考来源:US 3758528