Quinacainol, PK-10139
喹那卡诺Chemical Name: (?-2-(1,1-Dimethylethyl)-alpha-[2-(4-piperidinyl)ethyl]-4-quinolinemethanol; (?-2-tert-Butyl-alpha-[2-(4-piperidyl)ethyl]-4-quinolinemethanol; (?-1-[4-(2-tert-Butylquinolyl)]-3-(4-piperidyl)propanol
CAS No. 86024-64-8, 83255-74-7 (diHCl)
项目整合开发状态: Phase II
项目研究机构: Aventis Pharma (Originator), Pharmuka (Originator)
合成路线:The condensation of ethyl 3-(1-benzoyl-4-piperidyl)propionate (I) with ethyl 2-tert-butylquinoline-4-carboxylate (II) by means of NaH in refluxing THF gives 1-[4-(2-tert-butylquinolyl)]-3-(4-piperidyl)-1-propanone (III),which is then reduced with NaBH4 and NaOCH3 in methanol.
📌 参考资料/链接：
参考文献标题:Quinacainol
文献作者:Castar,J.; Serradell,M.N.; Koch,H.
参考来源:Drugs Fut 1984,9(4),273
📄 详细内容
合成路线:The condensation of ethyl 3-(1-benzoyl-4-piperidyl)propionate (I) with ethyl 2-tert-butylquinoline-4-carboxylate (II) by means of NaH in refluxing THF gives 1-[4-(2-tert-butylquinolyl)]-3-(4-piperidyl)-1-propanone (III),which is then reduced with NaBH4 and NaOCH3 in methanol.
参考文献标题:Medicaments based on derivatives of 1-(4-quinolyl)-2-(4-piperidyl)ethanol or 1-(4-quinolyl)-3-(4-piperidyl)propanol
文献作者:Gueremy,C.G.A.; Mestre,M.A.P.; Renault,C.L.A.
参考来源:EP 0053964; FR 2495470; US 4613607
产品链接: CAS No. 86024-64-8›› 产品链接: CAS No.83255-74-7››