Pentisomide, Penticainide, ME-3202, CM-7857
喷替索胺Chemical Name: 2-[2-(Diisopropylamino)ethyl]-4-methyl-2-(2-pyridyl)pentanamide; alpha-[2-[Bis(1-methylethyl)amino]ethyl]-alpha-(2-methylpropyl)-2-pyridineacetamide
CAS No. 78833-03-1, 96513-83-6 (racemate)
项目整合开发状态: Phase III
项目研究机构: Sanofi-Aventis (Originator), Meiji Seika (Licensee)
合成路线:The condensation of 2-pyridylacetonitrile (I) with isobutyraldehyde (II) in refluxing benzene gives 4-methyl-2-(2-pyridyl)-2-pentenenitrile (III),which is hydrogenated over Pd/C yielding 4-methyl-2-(2-pyridyl)pentanenitrile (IV).The alkylation of (IV) with 2-(diisopropylamino)ethyl chloride (A) in DMF affords 2-[2-(diisopropylamino)ethyl]-4-methyl-2-(2-pyridyl)pentanenitrile (V),which is then hydrolyzed in concentrated sulfuric acid.
📌 参考资料/链接：
参考文献标题:CM-7857
文献作者:Blancafort,P.; Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1983,8(12),1016
📄 详细内容
合成路线:The condensation of 2-pyridylacetonitrile (I) with isobutyraldehyde (II) in refluxing benzene gives 4-methyl-2-(2-pyridyl)-2-pentenenitrile (III),which is hydrogenated over Pd/C yielding 4-methyl-2-(2-pyridyl)pentanenitrile (IV).The alkylation of (IV) with 2-(diisopropylamino)ethyl chloride (A) in DMF affords 2-[2-(diisopropylamino)ethyl]-4-methyl-2-(2-pyridyl)pentanenitrile (V),which is then hydrolyzed in concentrated sulfuric acid.
参考文献标题:Synthesis and antiarrhythmic activity of new (dialkylamino)alkylpyridylacetamides
文献作者:Bernhart,C.A.; Condamine,C.; Demarne,H.; Roncucci,R.; Gagnol,J.P.; Gautier,P.; Serre,M.
参考来源:J Med Chem 1983,26(3),451
合成路线:The condensation of 2-pyridylacetonitrile (I) with isobutyraldehyde (II) in refluxing benzene gives 4-methyl-2-(2-pyridyl)-2-pentenenitrile (III),which is hydrogenated over Pd/C yielding 4-methyl-2-(2-pyridyl)pentanenitrile (IV).The alkylation of (IV) with 2-(diisopropylamino)ethyl chloride (A) in DMF affords 2-[2-(diisopropylamino)ethyl]-4-methyl-2-(2-pyridyl)pentanenitrile (V),which is then hydrolyzed in concentrated sulfuric acid.
参考文献标题:
文献作者:
参考来源:EP 0027412
产品链接: CAS No. 78833-03-1›› 产品链接: CAS No.96513-83-6››