Pentopril, CGS-13945
喷托普利Chemical Name: 1-(4-Ethoxycarbonyl-2,4(R,R)-dimethylbutanoyl)indoline-2(S)-carboxylic acid; [2S-[1-(alphaS*,gammaS*),2R*]]-2-Carboxy-2,3-dihydro-alpha,gamma-dimethyl-delta-oxo-1H-indole-1-pentanoic acid alpha-ethyl ester
CAS No. 82924-03-6
项目整合开发状态: Phase I
项目研究机构: Novartis (Originator)
合成路线:The ethanolysis of 2,4-dimethylglutaric anhydride (I) gives the monoethyl ester of 2,4-dimethylglutaric acid (II),which by reaction with oxalyl chloride is converted into the monoacyl chloride (III).Finally,this compound is condensed with indoline-2-carboxylic acid (IV) hy means of K2CO3 in pyridine.
📌 参考资料/链接：
参考文献标题:1-Carboxyalkanoylindolin-2-carboxylic acids and derivs.thereof,processes for their preparation,and pharmaceutical compsns.containing these cpds.as well as their use
文献作者:Gruenfeld,N.(Novartis AG)
参考来源:EP 0050850
📄 详细内容
合成路线:The ethanolysis of 2,4-dimethylglutaric anhydride (I) gives the monoethyl ester of 2,4-dimethylglutaric acid (II),which by reaction with oxalyl chloride is converted into the monoacyl chloride (III).Finally,this compound is condensed with indoline-2-carboxylic acid (IV) hy means of K2CO3 in pyridine.
参考文献标题:CGS-13945
文献作者:Serradell,M.N.; Castar,J.; Blancafort,P.
参考来源:Drugs Fut 1983,8(12),1010
产品链接: CAS No. 82924-03-6››