Zaltidine, CP-57361
唑替丁Chemical Name: [4-(2-Methylmidazol-5-yl)-2-thiazolyl]guanidine
CAS No. 85604-00-8, 90274-23-0 (diHCl)
项目整合开发状态: Phase II
项目研究机构: Pfizer (Originator)
合成路线:The bromination of 4-acetyl-2-methylimidazole (I) with Br2 in 48% HBr at 70 C gives 4-bromoacetyl-2-methylimidazole (II),which is then cyclized with amidinothiourea (III) in refluxing acetone.
📌 参考资料/链接：
参考文献标题:2-Guanidino-4-(2-methyl-4-imidazlyl)thiazoles in the treatment of rheumatoid arthritis
文献作者:Larson,D.L.(Pfizer Inc.)
参考来源:EP 0178822; JP 1986091122; US 4591595
📄 详细内容
合成路线:The bromination of 4-acetyl-2-methylimidazole (I) with Br2 in 48% HBr at 70 C gives 4-bromoacetyl-2-methylimidazole (II),which is then cyclized with amidinothiourea (III) in refluxing acetone.
参考文献标题:Zaltidine
文献作者:Castar,J.; Serradell,M.N.; Castar,R.M.
参考来源:Drugs Fut 1987,12(7),640
合成路线:The bromination of 4-acetyl-2-methylimidazole (I) with Br2 in 48% HBr at 70 C gives 4-bromoacetyl-2-methylimidazole (II),which is then cyclized with amidinothiourea (III) in refluxing acetone.
参考文献标题:Bioisosteric prototype design of biaryl imidazlyl and triazolyl competitive histamine H2-receptor antagonists
文献作者:Lipinski,C.A.; LaMattina,J.L.; Oates,P.J.
参考来源:J Med Chem 1986,29(11),2154-2163
产品链接: CAS No. 85604-00-8›› 产品链接: CAS No.90274-23-0››