Indomethacin butanediol ester, SY-6001
吲哚美辛 吲哚美辛 Chemical Name: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 2,3-butanediol monoester
CAS No. 53-86-1 (free acid), 74252-25-8 (Na salt, Trihydrate)
项目整合开发状态: Phase II
项目研究机构: SSP (Originator)
合成路线:The reaction of indomethacin (I) with SOCl2 in hot benzene gives the corresponding acyl chloride (II),which is then condensed with 2,3-butanediol (III) by means of pyridine in THF.
📌 参考资料/链接：
参考文献标题:Esters of indomethacin
文献作者:Isomae,K.; Kuwamura,T.; Mogi,K.; Ogawa,Y.; Sato,S.(SSP Co.,Ltd.)
参考来源:DE 3235850; GB 2125786
📄 详细内容
合成路线:The reaction of indomethacin (I) with SOCl2 in hot benzene gives the corresponding acyl chloride (II),which is then condensed with 2,3-butanediol (III) by means of pyridine in THF.
参考文献标题:SY-6001
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1986,11(3),194
产品链接: CAS No. 53-86-1›› 产品链接: CAS No.74252-25-8››