Indolidan, LY-195115
吲哚利旦Chemical Name: 1,3-Dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one
CAS No. 100643-96-7
项目整合开发状态: Phase II
项目研究机构: Lilly (Originator)
合成路线:Rearrangement of 2-methylpropanoic acid,2-phenylhydrazide (I) provides 1,3-dihydro-3,3-dimethyl-2H-indol-2-one (II).Friedel Crafts' acylation of (II) with succinic anhydride in an aluminum chloride/DMF melt results in the formation of 4-oxobutanoic acid (III).Cyclization of (III) with hydrazine in refluxing ethanol completes the preparation of LY-195115.
📌 参考资料/链接：
参考文献标题:LY-195115
文献作者:Hayes,J.S.; Robertson,D.W.
参考来源:Drugs Fut 1986,11(5),377
📄 详细内容
合成路线:Rearrangement of 2-methylpropanoic acid,2-phenylhydrazide (I) provides 1,3-dihydro-3,3-dimethyl-2H-indol-2-one (II).Friedel Crafts' acylation of (II) with succinic anhydride in an aluminum chloride/DMF melt results in the formation of 4-oxobutanoic acid (III).Cyclization of (III) with hydrazine in refluxing ethanol completes the preparation of LY-195115.
参考文献标题:Dihydropyridazinone cardiotonics: The discovery and inotropic activity of 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one
文献作者:Robertson,D.W.; et al.
参考来源:J Med Chem 1986,29(10),1832-40
产品链接: CAS No. 100643-96-7››