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项目整合精选>>>Indoramin hydrochloride, Wy-21901(free base), Doralese, Vidora, Wydora, Baratol
Indoramin hydrochloride, Wy-21901(free base), Doralese, Vidora, Wydora, Baratol
吲哌胺Chemical Name: 3-[2-(4-Benzamido-1-piperidyl)ethyl]indole hydrochloride; N-[1-[2-(1H-Indol-3-yl)ethyl]-4-piperidinyl]benzamide hydrochloride
CAS No. 26844-12-2 (free base)
项目整合开发状态: Launched-1981
项目研究机构: Wyeth Pharmaceuticals (Originator), GlaxoSmithKline (Not Determined), Shire Laboratories (Not Determined)
合成路线:The condensation of 3-(2-bromoethyl)indole (I) with 4-benzamidopyridine (II) in refluxing ethanol gives 4-benzamido-1-[2-(3-indolyl)ethyl]pyridinium bromide (III),which is reduced with H2 and Raney-Ni in ethanol containing triethylamine.
📌 参考资料/链接：
参考文献标题:Indoramin
文献作者:Sungurbey,K.; Castar,J.
参考来源:Drugs Fut 1976,1(10),476
📄 详细内容
合成路线:The condensation of 3-(2-bromoethyl)indole (I) with 4-benzamidopyridine (II) in refluxing ethanol gives 4-benzamido-1-[2-(3-indolyl)ethyl]pyridinium bromide (III),which is reduced with H2 and Raney-Ni in ethanol containing triethylamine.
参考文献标题:
文献作者:Archibald,J.L.; Jackson,J.L.
参考来源:ZA 6803204
产品链接: CAS No. 26844-12-2››