Piketoprofen, Calmatel
吡酮洛芬Chemical Name: m-Benzoyl-N-(4-methyl-2-pyridyl)hydratropamide; 3-Benzoyl-alpha-methyl-N-(4-methyl-2-pyridinyl)benzeneacetamide
CAS No. 60576-13-8
项目整合开发状态: Launched-1985
项目研究机构: Almirall Prodesfarma (Originator), Italfarmaco (Licensee)
合成路线:The reaction of 2-(3-benzoylphenyl)propionic acid (I) with SOCl2 or PCl3 gives the corresponding acyl chloride (II),which is then condensed with 4-methylpyridine-2-amine (III) by means of 4-methylpyridine in pyridine.
📌 参考资料/链接：
参考文献标题:Amide derivs.of 3-benzoyl-phenylalkanoic acids
文献作者:Vega Noverola,A.; Prieto Soto,J.; Spickett,R.G.W.
参考来源:GB 1436502
📄 详细内容
合成路线:The reaction of 2-(3-benzoylphenyl)propionic acid (I) with SOCl2 or PCl3 gives the corresponding acyl chloride (II),which is then condensed with 4-methylpyridine-2-amine (III) by means of 4-methylpyridine in pyridine.
参考文献标题:Procedimiento para la preparaci髇 de una amida de la 2-amino-4-metylpiridina
文献作者:Vega,A.; Prieto,J.; Moragues,J.(Fordonal SL)
参考来源:BE 0882711; ES 8102556; IT 1130573
产品链接: CAS No. 60576-13-8››