合成路线:The isomerization of methyl 3-oxo-1,2-benzothiazolin-1,1-dioxide-2-acetate (I) by means of sodium methoxide in DMSO gives methyl 3,4-dihydro-4-oxo-2H-1,2-benzothiazine-1,1-dioxide-3-carboxylate (II),which is methylated with methyl iodide and NaOH in methanol giving methyl 3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-1,1-dioxide-3-carboxylate (III).Finally,this product is treated with 2-aminopyridine (A) in refluxing xylene.
参考文献标题:Sudoxicam and related N.heterocyclic carboxamides of 4-hydroxy-2-methyl-2H-1,2-benzothiazine 1,1-dioxide,potent non steroidal anti-inflammatory agents
文献作者:Lombardino,J.G.; Wiseman,E.H.
参考来源:J Med Chem 1972,15(8),848
合成路线:The isomerization of methyl 3-oxo-1,2-benzothiazolin-1,1-dioxide-2-acetate (I) by means of sodium methoxide in DMSO gives methyl 3,4-dihydro-4-oxo-2H-1,2-benzothiazine-1,1-dioxide-3-carboxylate (II),which is methylated with methyl iodide and NaOH in methanol giving methyl 3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-1,1-dioxide-3-carboxylate (III).Finally,this product is treated with 2-aminopyridine (A) in refluxing xylene.
参考文献标题:Potent anti-inflammatory N-heterocyclic 3-carboxamides of 4-hydroxy-2-methyl-2H-1,2-benzothiazine 1,1-dioxide
文献作者:Lombardino,J.G.; Wiseman,E.H.; Chiaini,J.
参考来源:J Med Chem 1973,16(5),493
合成路线:The isomerization of methyl 3-oxo-1,2-benzothiazolin-1,1-dioxide-2-acetate (I) by means of sodium methoxide in DMSO gives methyl 3,4-dihydro-4-oxo-2H-1,2-benzothiazine-1,1-dioxide-3-carboxylate (II),which is methylated with methyl iodide and NaOH in methanol giving methyl 3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-1,1-dioxide-3-carboxylate (III).Finally,this product is treated with 2-aminopyridine (A) in refluxing xylene.
参考文献标题:Piroxicam
文献作者:Arrigoni-Martelli,E.; Castar,J.
参考来源:Drugs Fut 1977,2(2),124
产品链接: CAS No. 36322-90-4››