Oltipraz, RP-35972
吡噻硫酮Chemical Name: 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione
CAS No. 64224-21-1
项目整合开发状态: Phase II
项目研究机构: Aventis Pharma (Originator)
合成路线:The methylation of ethyl 3-pyrazinyl-3-oxopropionate (I) with methyl iodide and K2CO3 in acetone gives ethyl 2-methyl-3-pyrazinyl-3-oxopropionate (II),which is then treated with P2S5 in refluxing toluene.
📌 参考资料/链接：
参考文献标题:Oltipraz
文献作者:Hillier,K.; Blancafort,P.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1980,5(7),359
📄 详细内容
合成路线:The methylation of ethyl 3-pyrazinyl-3-oxopropionate (I) with methyl iodide and K2CO3 in acetone gives ethyl 2-methyl-3-pyrazinyl-3-oxopropionate (II),which is then treated with P2S5 in refluxing toluene.
参考文献标题:Nouveaux d閞iv閟 du dithiole-1,2,leur pr閜aration et les compositions qui les contiennent
文献作者:Bareau,M.; et al.
参考来源:BE 0851262; FR 2340730; JP 57081484; JP 57112391
产品链接: CAS No. 64224-21-1››