AZP
反式-2,4-二(1-氮丙啶基)-2,2,4,4,6,6-六氢-2,4,6,6-四(甲基氨基)-1,3,5,2,4,6-三氮杂三磷杂苯Chemical Name: trans-2,4-Bis(1-aziridinyl)-2,2,4,4,6,6-hexahydro-2,4,6,6-tetrakis(methylamino)-1,3,5,2,4,6-triazatriphosphorine
CAS No. 89631-66-3
项目整合开发状态: Phase II
项目研究机构: Rijksuniversiteit Groningen (Originator)
合成路线:To a stirred solution of trans N3P3Az2Cl4 (I) in 15 ml of benzene,cooled to 5 C,a solution of 50 mmol of MeNH2 in 20 ml of benzene is added dropwise.After warming to room temperature and allowing the reaction to proceed over a period of 18 h,the temperature of the reaction mixture is raised to 50 C for an additional 6 h.The precipitated amine hydrochloride salt is filtered off and washed with benzene.The washings are combined with the filtrate and evaporated by vacuum.The crude product is recrystallized from benzene
📌 参考资料/链接：
参考文献标题:AZP
文献作者:Eastland,G.
参考来源:Drugs Fut 1988,13(9),815
📄 详细内容
合成路线:To a stirred solution of trans N3P3Az2Cl4 (I) in 15 ml of benzene,cooled to 5 C,a solution of 50 mmol of MeNH2 in 20 ml of benzene is added dropwise.After warming to room temperature and allowing the reaction to proceed over a period of 18 h,the temperature of the reaction mixture is raised to 50 C for an additional 6 h.The precipitated amine hydrochloride salt is filtered off and washed with benzene.The washings are combined with the filtrate and evaporated by vacuum.The crude product is recrystallized from benzene
参考文献标题:Isomer-dependent cytostatic activity of bis(1-azir
文献作者:van der Huizen,A.A.; Wilting,T.; van de Grampel,J.C.; Lelieveld,P.; van der Meer-Kalverkamp,A.; Lamberts,H.B.; Mulder,N.H.
参考来源:J Med Chem 1986,291341
产品链接: CAS No. 89631-66-3››