Bisnafide mesylate, Bisnafide mesilate, NSC-D640430, DMP-840
双奈法德 双奈法德 Chemical Name: (R,R)-2,2'-(Ethane-1,2-diyl)bis[imino(1-methylethane-2,1-diyl)]bis(5-nitro-2,3-dihydro-1H-benzo[de]isoquinoline-1,3-dione) dimethanesulfonate; (R,R)-2,2'-(Ethylenediimino)bis(1-methyl-2,1-ethanediyl)bis(5-nitro-2,3-dihydro-1H-benzo[de]isoquinoline-1,3-dione) dimethanesulfonate
CAS No. 145124-30-7, 144849-63-8 (free base)
项目整合开发状态: Phase II
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:The condensation of tert-butoxycarbonyl-D-alanine (I) with ethylenediamine (II) gives the corresponding protected diamide (III),which is deprotected in acidic medium to the diamide (IV).The reduction of (IV) with diborane in THF yields the (R,R)-4,7-diazadecane-2,9-diamine (V),which is finally condensed with 3-nitronaphthalene-1,8-dicarboxylic acid anhydride (VI) in refluxing ethanol and salified with methanesulfonic acid.
📌 参考资料/链接：
参考文献标题:Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
文献作者:Sun,J.-H.(DuPont Pharmaceuticals Co.)
参考来源:EP 0506008; EP 0577753; JP 1994506229; US 5206249; WO 9217453
📄 详细内容
合成路线:The condensation of tert-butoxycarbonyl-D-alanine (I) with ethylenediamine (II) gives the corresponding protected diamide (III),which is deprotected in acidic medium to the diamide (IV).The reduction of (IV) with diborane in THF yields the (R,R)-4,7-diazadecane-2,9-diamine (V),which is finally condensed with 3-nitronaphthalene-1,8-dicarboxylic acid anhydride (VI) in refluxing ethanol and salified with methanesulfonic acid.
参考文献标题:Bisnafide Mesylate
文献作者:Robinson,C.P.; Robinson,K.A.; Castar,J.
参考来源:Drugs Fut 1996,21(3),239
产品链接: CAS No. 145124-30-7›› 产品链接: CAS No.144849-63-8››