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项目整合精选>>>Dithiosteine, Erdosteine, KW-9144, RV-144, Erdotin, Tussol, Vectrine, Edirel
Dithiosteine, Erdosteine, KW-9144, RV-144, Erdotin, Tussol, Vectrine, Edirel
厄多司坦Chemical Name: (?-S-[2-Oxo-2-(2-oxothien-3-ylamino)ethyl]thioglucolicacid; (?-2-[2-Oxo-2-(oxothien-3-ylamino)ethylsulfanyl]acetic acid; (?-3-[2-(Carboxymethylsulfanyl)acetamido]tetrahydrothiophen-2-one; (?-N-(Carboxymethylsulfanylacetyl)homocysteine thiolactone
CAS No. 84611-23-4
项目整合开发状态: Launched-1995
项目研究机构: REFARMED (Originator), Alfa Wassermann (Licensee), Biomedica Foscama (Licensee), Edmond Pharma (Licensee), Kyowa Hakko (Licensee), Merckle (Licensee), Negma (Licensee), Provalis (Licensee), Sigma-Tau (Licensee), Vitor (Licensee)
合成路线:Erdosteine (III) can be obtained in a two-step synthesis starting from homocysteine thiolactone (I).(I) is acylated in chloroform with chloroacetyl chloride (A) to the amide (II).Subsequent reaction with thioglycolic acid (B) gives rise to (III).
📌 参考资料/链接：
参考文献标题:ERDOSTEINE < Rec INN >
文献作者:Fregnan,G.B.; Pappalardo,M.
参考来源:Drugs Fut 1990,15(9),887
📄 详细内容
合成路线:Erdosteine (III) can be obtained in a two-step synthesis starting from homocysteine thiolactone (I).(I) is acylated in chloroform with chloroacetyl chloride (A) to the amide (II).Subsequent reaction with thioglycolic acid (B) gives rise to (III).
参考文献标题:DL-S-[2-[N-3-(2-Oxotetrahydrothienyl)acetamido]]-thioglycolic acid: A novel mucolytic agent of the class of homocysteine thiolactone derivatives
文献作者:Gobetti,M.; Pedrazzoli,A.; Bradamante,S.
参考来源:Farm Sci Ed 1986,41(1),69-79
产品链接: CAS No. 84611-23-4››