Pimobendan, UD-CG-115BS, UD-CG-115, Acardi
匹莫苯丹Chemical Name: 6-[2-(4-Methoxyphenyl)-1H-benzimidazol-5-yl]-5-ylmethyl-2,3,4,5-tetrahydropyridazin-3-one
CAS No. 74150-27-9, 118428-36-7 (racemate)
项目整合开发状态: Launched-1994
项目研究机构: Boehringer Ingelheim (Originator)
合成路线:The cyclization of methyl 3-[4-(4-methoxybenzoylamino)-3-nitrobenzoyl]butyrate (I) with hydrazine hydrate in refluxing acetic acid gives 4,5-dihydro-6-[4-(4-methoxybenzoylamino)-3-nitrobenzoyl]-5-methylpyridazin-3(2H)-one (II),which is reduced with H2 over Pd/C in ethanol yielding the corresponding amino derivative (III).Finally,this compound is cyclized in refluxing acetic acid.
合成路线:By condensation of norbornane-2,3-di-endo-carboxylic anhydride (I) with 1-(4-aminobutyl)-4-(2 pyrimidinyl)piperazine (II) in refluxing pyridine.
📌 参考资料/链接：
参考文献标题:Succimide derivatives,compositions and method of use
文献作者:Ishizumi,K.; Antoku,F.; Asami,Y.(Sumitomo Chemical Co.,Ltd.)
参考来源:CA 1184915; EP 0082402
📄 详细内容
合成路线:The cyclization of methyl 3-[4-(4-methoxybenzoylamino)-3-nitrobenzoyl]butyrate (I) with hydrazine hydrate in refluxing acetic acid gives 4,5-dihydro-6-[4-(4-methoxybenzoylamino)-3-nitrobenzoyl]-5-methylpyridazin-3(2H)-one (II),which is reduced with H2 over Pd/C in ethanol yielding the corresponding amino derivative (III).Finally,this compound is cyclized in refluxing acetic acid.
参考文献标题:Pimobendan
文献作者:Mannhold,R.
参考来源:Drugs Fut 1985,10(7),570
产品链接: CAS No. 74150-27-9›› 产品链接: CAS No.118428-36-7››