Pineprofen, Ibuprofen piconol, BE-100, Vesicum, Staderm
匹美诺芬Chemical Name: Ibuprofen 2-pyridylmethyl ester; 2-(4-Isobutylphenyl)propionic acid 2-pyridylmethyl ester; alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid 2-pyridinylmethyl ester
CAS No. 64622-45-3
项目整合开发状态: Launched-1984
项目研究机构: Hisamitsu (Originator), Torii (Originator)
合成路线:This compound can be obtained in two different ways:1) By reaction of 2-(p-isobutylphenyl)propionic acid sodium salt (I) with 2-pyridylmethyl chloride (II) in refluxing benzene.2) By reaction of 2-(p-isobutylphenyl)propionyl chloride (III) with 2-pyridylmethanol (IV) by means of triethylamine in THF.
📌 参考资料/链接：
参考文献标题:Pyridylalkyl esters of 2-(p-isobutylphenyl)acetic acid and propionic acids and use
文献作者:Noda,K.; Nakagawa,A.; Ishikura,Y.; Tosu,S.; Ide,H.(Hisamitsu Pharmaceutical Co.,Ltd.)
参考来源:US 4150137
📄 详细内容
合成路线:This compound can be obtained in two different ways:1) By reaction of 2-(p-isobutylphenyl)propionic acid sodium salt (I) with 2-pyridylmethyl chloride (II) in refluxing benzene.2) By reaction of 2-(p-isobutylphenyl)propionyl chloride (III) with 2-pyridylmethanol (IV) by means of triethylamine in THF.
参考文献标题:Pineprofen
文献作者:Castar,J.; Blancafort,P.; Serradell,M.N.
参考来源:Drugs Fut 1982,7(6),401
产品链接: CAS No. 64622-45-3››