ME-3221
化合物 T28009Chemical Name: 3-Methoxy-2,6-dimethyl-4-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethoxy]pyridine
CAS No. 139958-16-0
项目整合开发状态: Phase I
项目研究机构: Meiji Seika (Originator)
合成路线:The condensation of 3-methoxy-2,6-dimethylpyridin-4(1H)-one (I) with 5-[4'-(bromomethyl)biphenyl-2-yl]-1-(triphenylmethyl)tetrazole (II) by means of NaH in hot DMF gives the condensation product (III),which is finally deprotected by treatment with HCl in methanol/dichloromethane.
📌 参考资料/链接：
参考文献标题:Pyridine derivs.with angiotensin II antagonism
文献作者:Katano,K.; Ogino,H.; Shitara,E.; Watanabe,H.; Nagura,J.; Osada,N.; Ichimaru,Y.; Konno,F.; Machinami,T.; Tsuruoka,T.(Meiji Seika Kaisha,Ltd.)
参考来源:EP 0487745; US 5399566; WO 9119697
📄 详细内容
合成路线:The condensation of 3-methoxy-2,6-dimethylpyridin-4(1H)-one (I) with 5-[4'-(bromomethyl)biphenyl-2-yl]-1-(triphenylmethyl)tetrazole (II) by means of NaH in hot DMF gives the condensation product (III),which is finally deprotected by treatment with HCl in methanol/dichloromethane.
参考文献标题:ME-3221
文献作者:Mealy,N.; Ngo,J.; Castar,J.
参考来源:Drugs Fut 1996,21(8),794
产品链接: CAS No. 139958-16-0››