合成路线:This compound has been obtained by two different ways:1) The reaction of dipropylcarbinol (I) with HBr gives 4-bromoheptane (II),which is treated with KCN to yield 2-propylpentanenitrile (III).Finally,this compound is hydrolyzed to the target compound with NaOH or with H2SO4.2) The condensation of cyanacetic acid ethyl ester (IV) with propyl bromide (V) by means of sodium propoxide in propanol gives crude dipropylcyanaacetic acid ethyl ester,which,without isolation,is hydrolyzed with NaOH in hot water yielding dipropylcyanacetic acid (VI).The decarboxylation of (VI) at 140-190 C affords the previously reported 2-propylpentanenitrile (III).
参考文献标题:Process for preparing acetic acid derivs.
文献作者:Pigerol,C.; Grain,C.; Chignac,M.(Labaz)
参考来源:GB 1529786
合成路线:This compound has been obtained by two different ways:1) The reaction of dipropylcarbinol (I) with HBr gives 4-bromoheptane (II),which is treated with KCN to yield 2-propylpentanenitrile (III).Finally,this compound is hydrolyzed to the target compound with NaOH or with H2SO4.2) The condensation of cyanacetic acid ethyl ester (IV) with propyl bromide (V) by means of sodium propoxide in propanol gives crude dipropylcyanaacetic acid ethyl ester,which,without isolation,is hydrolyzed with NaOH in hot water yielding dipropylcyanacetic acid (VI).The decarboxylation of (VI) at 140-190 C affords the previously reported 2-propylpentanenitrile (III).
参考文献标题:Process for the preparation of acetonitrile deriv.
文献作者:Grain,C.; Chignac,M.; Pigerol,C.(Labaz)
参考来源:US 4155929
合成路线:This compound has been obtained by two different ways:1) The reaction of dipropylcarbinol (I) with HBr gives 4-bromoheptane (II),which is treated with KCN to yield 2-propylpentanenitrile (III).Finally,this compound is hydrolyzed to the target compound with NaOH or with H2SO4.2) The condensation of cyanacetic acid ethyl ester (IV) with propyl bromide (V) by means of sodium propoxide in propanol gives crude dipropylcyanaacetic acid ethyl ester,which,without isolation,is hydrolyzed with NaOH in hot water yielding dipropylcyanacetic acid (VI).The decarboxylation of (VI) at 140-190 C affords the previously reported 2-propylpentanenitrile (III).
参考文献标题:
文献作者:Walles,M.; et al.
参考来源:Z Physiolog Chem 1947,282(2),137
合成路线:By reaction of valproic acid (I) with NaOH in water - acetonitrile (II).
参考文献标题:Process for making sodium hydrogen divalproate
文献作者:Fischer,F.E.
参考来源:AR 226077; CA 1144558; GR 70721
合成路线:By reaction of valproic acid (I) with NaOH in water - acetonitrile (II).
参考文献标题:Valproate semisodium
文献作者:Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1984,9(8),595
产品链接: CAS No. 76584-70-8››