Linogliride, McN-3935
利诺格列 N-(1-甲基-2-吡咯烷基亚基)-N'-苯基-4-吗啉甲脒富马酸盐 Chemical Name: N-(1-Methyl-2-pyrrolidinylidene)-N'-phenyl-4-morpholinecarboxamidine; N-(1-Methyl-2-pyrrolidinylidene)-N'-phenyl-4-morpholinecarboximidamide
CAS No. 75358-37-1, 78782-47-5 (fumarate)
项目整合开发状态: Phase II
项目研究机构: Ortho-McNeil (Originator)
合成路线:The reaction of phenyl isothiocyanate (I) with 2-imino-1-methyl pyrrolidine (II) in benzene gives N-(1-methyl-2-pyrrolidinylidene)-N'-phenylthiourea (III),which is treated with iodomethane in refluxing acetone to afford methyl N-1-methyl-2-pyrrolidinylidene)-N'-phenylcarbamidothioate (IV).Finally,this compound is treated with morpholine in refluxing isopropanol.
📌 参考资料/链接：
参考文献标题:Nitrogen heterocyclic carboximidamide compounds
文献作者:Rasmussen,C.R.(Ortho-McNeil Pharmaceutical,Inc.)
参考来源:US 4211867
📄 详细内容
合成路线:The reaction of phenyl isothiocyanate (I) with 2-imino-1-methyl pyrrolidine (II) in benzene gives N-(1-methyl-2-pyrrolidinylidene)-N'-phenylthiourea (III),which is treated with iodomethane in refluxing acetone to afford methyl N-1-methyl-2-pyrrolidinylidene)-N'-phenylcarbamidothioate (IV).Finally,this compound is treated with morpholine in refluxing isopropanol.
参考文献标题:Linogliride
文献作者:Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1986,11(4),265
产品链接: CAS No. 75358-37-1›› 产品链接: CAS No.78782-47-5››