Limazocic, SA-3443
利马西克Chemical Name: (-)-4(R)-Hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithiazocine-4-carboxylic acid
CAS No. 128620-82-6
项目整合开发状态: Phase II
项目研究机构: Santen (Originator)
合成路线:By oxidative cyclization of N-(3-mercapto-2,2-dimethylpropionyl)-L-cysteine (I) by means of I2 in dichloromethane,diethyl bromomalonate and triethylamine in the same solvent.
📌 参考资料/链接：
参考文献标题:Cyclic sulfur-containing cpds
文献作者:Morita,T.; Mita,S.; Iso,T.; Kawashima,Y.(Santen Pharmaceutical Co.,Ltd.)
参考来源:EP 0356006; US 5041435
📄 详细内容
合成路线:By oxidative cyclization of N-(3-mercapto-2,2-dimethylpropionyl)-L-cysteine (I) by means of I2 in dichloromethane,diethyl bromomalonate and triethylamine in the same solvent.
参考文献标题:SA-3443
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1992,17(7),566
产品链接: CAS No. 128620-82-6››