Ridazolol
利达洛尔Chemical Name: (?-4-Chloro-5-[[2-[[3-(o-chlorophenoxy)-2-hydroxypropyl]amino]ethyl]amino]-3(2H)-pyridazinone
CAS No. 83395-21-5, 83394-57-4 (monoHCl)
项目整合开发状态: Phase II
项目研究机构: Cassella (Originator)
合成路线:The condensation of 2-glycidyloxy-1-chlorobenzene (I) with ethylenediamine (II) in refluxing ethanol gives N-[3-(2-chlorophenoxy)-2-hydroxy propyl]ethylenediamine (III),which is then condensed with 4,5-dichloropyridazinone (IV) in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:N-phenoxypropanol-N'-pyridazinyl ethylendiamines as beta -receptor blockers
文献作者:Raabe,T.; Bohn,H.; Martorana,P.A.; Nitz,R.-E.(Cassella AG)
参考来源:DD 202013; DE 3048487; EP 54946; JP 57128677; US 4532239
📄 详细内容
合成路线:The condensation of 2-glycidyloxy-1-chlorobenzene (I) with ethylenediamine (II) in refluxing ethanol gives N-[3-(2-chlorophenoxy)-2-hydroxy propyl]ethylenediamine (III),which is then condensed with 4,5-dichloropyridazinone (IV) in refluxing ethanol.
参考文献标题:Ridazolol
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1986,11(12),1044
产品链接: CAS No. 83395-21-5››