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项目整合精选>>>Risedronate sodium, NE-58095, Optinate Septimum, Benet, Optinate, Actonel
Risedronate sodium, NE-58095, Optinate Septimum, Benet, Optinate, Actonel
利赛膦酸钠 利塞膦酸 Chemical Name: 2-(3-Pyridinyl)-1-hydroxyethane-1,1-biphosphonate monosodium salt; [2-(3-Pyridyl)ethylidene]hydroxydiphosphonate monosodium salt; 1-Hydroxy-2-(3-pyridyl)ethane-1,1-diphosphonic acid monosodium salt
CAS No. 115436-72-1, 105462-24-6 (free acid)
项目整合开发状态: Launched-1998
项目研究机构: Procter & Gamble (Originator), Ajinomoto (Licensee), Aventis Pharma (Licensee), Lepetit (Licensee), Eisai (Codevelopment), Takeda (Codevelopment)
合成路线:Risedronic acid is prepared by treatment of 2-(3-pyridyl)acetic acid (I) with a mixture of phosphorous acid and phosphorus oxychloride at reflux for 2.5 h.
📌 参考资料/链接：
参考文献标题:Pharmaceutical compsns.containing geminal diphosphonates
文献作者:Benedict,J.J.; Perkins,C.M.(The Procter & Gamble Co.)
参考来源:AU 8551534; EP 0186405; ES 8707543; JP 1995285976; JP 1997202794; US 5583122
📄 详细内容
合成路线:Risedronic acid is prepared by treatment of 2-(3-pyridyl)acetic acid (I) with a mixture of phosphorous acid and phosphorus oxychloride at reflux for 2.5 h.
参考文献标题:Risedronate Sodium
文献作者:Mealy,N.; Castar,J.; Prous,J.
参考来源:Drugs Fut 1993,18(7),605
产品链接: CAS No. 115436-72-1›› 产品链接: CAS No.105462-24-6››