Roquinimex, PNU-212616, FCF-89, LS-2616, Linomide

利诺安Chemical Name: 4-Hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydro-3-quinolinecarboxamide
CAS No. 84088-42-6
项目整合开发状态: Phase III
项目研究机构: Leo (Originator), Pfizer (Originator)
合成路线:By condensation of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ethyl ester (I) with N-methylaniline (II) by heating at 125 C and distillation of the ethanol formed.

合成路线:The oxidative cleavage of methyl beta-L-arabinopyranoside (I) with sodium periodate in water gives the dialdehyde (II),which is then cyclized with daunorubicin by means of NaHCO3 and sodium cyanoborohydride in acetonitrile/water.