Rilmenidine dihydrogen phosphate, S-3341, Hyperium
利美尼啶Chemical Name: 2-(alpha,alpha-Dicyclopropylmethylamino)-2-oxazoline dihydrogen phosphate; 2-(alpha,alpha-Dicyclopropylmethylamino)-4,5-dihydrooxazole dihydrogen phosphate; alpha,alpha-Dicyclopropyl-N-(4,5-dihydrooxazol-2-yl)methylamine dihydrogen phosphate; N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine dihydrogen phosphate
CAS No. 54187-04-1, 54249-57-9 ((E)-2-butenedioate (1:1))
项目整合开发状态: Launched-1988
项目研究机构: Servier (Originator)
合成路线:The addition of dicyclopropylmethylamine (II) to B-chloroethyl isocyanate (I) in THF gives N-(dicyclopropylmethyl)-N'-(Beta-chloroethyl)urea (III),which is then cyclized in refluxing water.
📌 参考资料/链接：
参考文献标题:Cyclopropylamines as pharmaceuticals
文献作者:Malen,C.; Desnos,M.; Laubie,M.; Poignant,J.C.(Servier Laboratoires)
参考来源:DE 2362754; ES 421879; FR 2212143; GB 1453703; JP 50004084; JP 53056664; JP 53056665
📄 详细内容
合成路线:The addition of dicyclopropylmethylamine (II) to B-chloroethyl isocyanate (I) in THF gives N-(dicyclopropylmethyl)-N'-(Beta-chloroethyl)urea (III),which is then cyclized in refluxing water.
参考文献标题:S-3341
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1986,11(6),470
产品链接: CAS No. 54187-04-1››